Following the recent stopping of the Intensive control arm of the ACCORD study of  patients with Type 2 diabetes because of an excess of deaths in this group, the investigators in the Australian ADVANCE study ran a preliminary analysis of their data, and found no increase in deaths in their Intensive control patients. This will come as a relief to any of you who were worried that tight control might actually be bad for you. There are some differences between the studies - the ADVANCE patients did not already have the same degree of cardiovascular risk factors as those in ACCORD, and the US patients were even more intensively treated with insulin.

So the message as far as I’m concerned still is - go for good control.

TW

Interesting commentary in the Journal of the American Medical Association recently about how abnormal fat metabolism is the root cause of Type 2 diabetes. The author suggests that accumulation of fats in body cells causes insulin resistance and therefore Type 2 diabetes. The fats, he says get deposited in body cells because people eat too much, and he’s probably right, but he doesn’t address the question of what sort of eating too much is particularly bad for you. The current view seems to be that excess calories make you fat, and that since dietary fat contains 9 kcal per gram, this is worse than carbohydrate, which has about 4 kcal per gram, but in fact, what really cause fat to be laid down in cells is insulin, and this is only produced when you take in carbohydrate. So, the theory may be right, but the detail, as always is vital to the message.

 The report is by Unger, JAMA, March 12 2008, Vol 299, No 10, 1185-7.

You will no doubt be seeing in the newspapers in the next few days that one part of the huge ACCORD trial in patients with Type 2 diabetes has been stopped because of an increased death rate in the group of people assigned to intensive blood glucose control. This is a great shock and no doubt will be taken by some people to indicate that good control of blood glucose may be a bad thing.

No single drug or set of drugs could be identified as being responsible for this, but it all the people in this group were receiving multiple treatments for the diabetes and many of them were using insulin as well as tablets. They did seem to have better blood glucose control in that the haemoglobin A1c levels were significantly lower than in the standard treatment group, but despite this more of them died during thestudy period than in the standard treatment group.

As ever, these results need to be viewed with some care. The group of people included in the study not only had had diabetes for an average of 10 years and were relatively old, but they also had poor control and known heart disease or at least two other risk factors. Although their death rate appeared to be higher in the intensive control group, the rate of non-fatal heart attacks was actually lower and there was no consistent cause of the excess of deaths.

Previous studies have suggested that lifestyle measures leading to better blood glucose control can slow the progress of the condition and reverse some of the complications so this result really does come as a surprise.

The first thing to say is that the results may be a statistical anomaly, which are not that uncommon in large trials of this type (remember the HRT trials?). The second is that it is not the lower blood glucose levels that are likely to be causing the deaths, but rather the treatments. Modern views of diabetes care (not yet promoted by either the American Diabetes Association or Diabetes UK) might say that most of the treatments, and particularly insulin in Type 2 diabetes may well cause more problems than they cure.

You will find a good discussion at: http://www.healthcentral.com/diabetes/c/5068/20145/study-whats/1/

If you want to look at the detail and see what the ACCORD study is all about you can find it at http ://www.nhlbi.nih.gov/health/prof/heart/other/accord/index.htm.

In the meanwhile DON’T CHANGE YOUR TREATMENT! Good glucose control matters.

Tony Woolfson